ABSTRACT
Mucormycosis (MM) is an invasive fungal infection that causes severe systemic infections and poses health risks and threat to life. Despite its impact on human health, MM infection is neglected and underrepresented compared to other infections. Invasiveness of MM severely compromises systemic and metabolic functions of the hepatic system, degeneration of lungs, trachea, and alveoli epithelial cell with increased fatality rate, and associated risk with therapeutic use of glucocorticoids in COVID-19. In Africa, the prevalence rate remains unknown due to late prognosis and non-reportability of the disease. Hence, there is a need to include MM diagnosis in patients with COVID-19, increase surveillance of emerging clonal strains, and regulate the routine glucocorticoids use in COVID-19 infection therapy. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
ABSTRACT
Maternal insults during pregnancy induces an increased risk of autism spectrum disorders (ASD) in offspring, but the neuropathological changes in this process remains not to be established. To shed light on this, the transcriptome datasets of maternal blood samples with children later diagnosed with ASD and typical development, and tissue samples of multiple brain regions from ASD patients and human neurodevelopment were conducted to identify the non-chasm differentially expressed genes (DEGs) to generate the spatio-temporal dynamic change. Combined enrichment and interaction network analysis revealed that non-chasm DEGs with similar expression trajectories in the same brain regions, were involved in neural, immune and metabolic GO functions and KEGG pathways, respectively, suggesting that did not performed exactly the same functions. Interestingly, our results found that non-chasm DEGs in frontal cortex and temporal cortex were associated with COVID-19, suggesting that as an environmental risk factor COVID-19 affects an increased risk of ASD.